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Multiplexed CRISPR/Cas9 mediated knockdown of BCH gene in potato enhances beta-carotene to combat Vitamin A Deficiency.

Plant science : an international journal of experimental plant biology | 2026-Aug-09

This study utilizes a multiplexed CRISPR/Cas9 system to knock down the beta-carotene hydroxylase (BCH) gene in potato, resulting in a significant reduction of BCH transcripts. The genome-edited potato lines showed a substantial increase in beta-carotene levels in the tubers, providing a potential strategy for biofortification to address Vitamin A deficiency.